Posts Tagged ‘Recovery Centers of King County’

Frontal Systems Dysfunction in Stimulant Abusers – Results from CTN-0031-A-1

September 12, 2012

Currently in-press at Drug and Alcohol Dependence, and written by Theresa Winhusen, Eugene Somoza, Daniel Lewis, and colleagues, this article reports on the ancillary protocol CTN-0031-A-1, “An Evaluation of Neurocognitive Function, Oxidative Damage, and Their Association with Treatment Outcomes in Methamphetamine and Cocaine Abusers.”  Recovery Centers of King County, part of the Pacific Northwest Node, participated in this study.

Frontal systems dysfunction is present in stimulant-dependent patients. However, it is unclear whether this dysfunction is a pre-morbid risk factor or stimulant-induced, is severe enough to be clinically relevant, and if it is relevant to treatment response. These questions were addressed using the Frontal Systems Behavior Scale (FrSBe), a reliable and valid self-report assessment of three neurobehavioral domains associated with frontal systems functioning (Apathy, Disinhibition, and Executive Dysfunction, summed for a Total), that assesses both pre- and post-morbid functioning, and has a specific cutoff for defining clinically significant abnormalities.

Analysis of results revealed that stimulant-dependent patients evidence frontal systems dysfunction as measured by the FrSBe, that frontal systems dysfunction was present prior to the initiation of stimulant abuse based on retrospective ratings, that stimulant use was associated with significant worsening of frontal systems function, and that clinically significant Disinhibition was associated with poorer treatment response.

Citation: Winhusen TM, Somoza EC, Lewis DF, et al. Frontal Systems Deficits in Stimulant-Dependent Patients: Evidence of Pre-Illness Dysfunction and Relationship to Treatment Response. Drug and Alcohol Dependence 2012 (in press).


Find it in the CTN Dissemination Library!

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PN Node Authors in JSAT’s Special Supplement: A Decade of Research in the CTN

March 30, 2010

In honor of the CTN’s 10th anniversary, the Journal of Substance Abuse Treatment presents “A Decade of Research by the National Drug Abuse Treatment Clinical Trials Network.”

This special supplement features overview articles describing the completed studies and outcomes from the past decade of CTN research. It also reviews several ancillary investigations, where data from original CTN protocols is examined in a new way to reveal new correlations and propose future research.

Five articles in the issue are co-authored by researchers and clinicians from the Pacific Northwest node:

Ron Jackson, from Evergreen Treatment Services, cowrote “The First Decade of the National Drug Abuse Treatment Clinical Trials Network: Bridging the Gap Between Research and Practice to Improve Drug Abuse Treatment,” which reviews the rationale for the CTN, describes the translation of its guiding principles into research endeavors, and anticipates the future evolution of clinical research within the Network.

In “Study Results from the Clinical Trial Network’s First 10 Years: Where Do They Lead?Elizabeth (Betsy) Wells, Don Calsyn and Dennis Donovan from ADAI, Andrew Saxon from the VA Puget Sound, and Ron Jackson from Evergreen Treatment Services, review the completed (to date) protocols in the CTN with the aim of identifying the incremental progress toward improving drug treatment made by these trials.

From Research to the Real World: Buprenorphine in the Decade of the Clinical Trials Network,” was co-written by Andrew Saxon of the VA Puget Sound, and reviews the 6 CTN  buprenorphine protocols (CTN-0001/2, 0003, 0010, 0027, 0030), describing related efforts to overcome challenges to the implementation of buprenorphine therapy in mainstream practice.

Jessica DiCenzo from Recovery Centers of King County, a PN Node CTP, was co-author for “Predicting Outpatient Treatment Entry Following Detoxification for Injection Drug Use: The Impact of Patient and Program Factors.”  This secondary analysis of data from CTN-0017  examined variables predicting outpatient treatment entry within six months of residential detoxification.

And finally, Don Calsyn from ADAI co-authored “Multisite Effectiveness Trials of Treatments for Substance Abuse and Co-Occurring Problems: Have We Chosen the Best Designs?”  This article systematically examines, for each of the completed CTN protocols, the experimental design type chosen and its original rationale, the main findings of the trials, and the strengths and weaknesses of the design in hindsight.

Congratulations to all our Pacific Northwest Node authors!

Find these articles and all the others from the JSAT special supplement in the CTN Dissemination Library.