This paper, currently in-press at Contemporary Clinical Trials and co-written by Andrew Saxon of the Pacific Northwest Node, describes the design, methods, and aims of National Drug Abuse Treatment Clinical Trials Network protocol CTN-0048, Cocaine Use Reduction with Buprenorphine (CURB).
CURB was developed to examine the safety and efficacy of sublingual buprenorphine (as Suboxone) in the presence of extended-release injectable naltrexone to see whether that combination reduces cocaine use in adults with both cocaine dependence and opioid use disorders. Investigators also want to determine whether or not the addition of naltrexone prevents development of physiologic dependence on buprenorphine.
Recruitment commenced in September 2011 — Recovery Centers of King County from our node is one of the participating CTPs — and enrollment, active medication, and follow-up phases are ongoing.
Citation: Mooney LJ, Nielsen S, Saxon AJ, et al. Cocaine Use Reduction with Buprenorphine (CURB): Rationale, Design, and Methodology. Contemporary Clinical Trials 2012 (in press).