Archive for August, 2018

Dennis Donovan Retiring as Director of the UW Alcohol & Drug Abuse Institute

August 29, 2018

donovan2017After twenty-five years, Dr. Dennis Donovan is stepping down as Director of the Alcohol & Drug Abuse Institute at the University of Washington.  He will continue his work in the CTN as the Co-PI (with Dr. Mary Hatch-Maillette) of the Pacific Northwest Node, member of the CTN Publications Committee, as well as selected other activities within the CTN, ADAI, and the UW, under his new status as Professor Emeritus.

Dennis M. Donovan has been the director of the Alcohol and Drug Abuse Institute since 1993 and a UW faculty member since 1981; he has been a Professor in Psychiatry & Behavioral Sciences and Adjunct Professor in the UW Departments of Psychology, Health Services, and Global Health.  He also directed the Substance Abuse and HIV/STI Scientific Working Group within the UW’s Center for AIDS Research. Dr. Donovan has been a Principal Investigator of numerous federally funded grants, including NIAAA’s Project MATCH, the NIAAA COMBINE Study, and NIDA’s National Drug Abuse Treatment Clinical Trials Network (CTN).  He has published more than 300 articles, chapters, and books in the area of alcoholism and addictive behaviors.

Before coming to ADAI, Dr. Donovan was affiliated with the Addictions Treatment Center at the Seattle Division of the Department of Veterans Affairs Puget Sound Health Care System for over 20 years, involved in clinical, administrative, training, and research activities. At the VA he directed the Inpatient Treatment Program and Assistant Director of the Addictions Treatment Center. Prior to moving full time to the University of Washington and ADAI, he served as the Associate Director and then Acting Director of the first Center of Excellence in Substance Abuse Treatment and Education (CESATE) within the Department of Veterans Affairs nationally. Among his many contributions within the VA system was the development of the first interdisciplinary fellowship in substance abuse treatment, including postdoctoral clinical psychologists, and post-masters nursing, social work, and occupational therapist trainees. In 2013, he was invited to serve on the Institute of Medicine’s (IOM) Committee for an Evaluation of the Department of Veterans Affairs Mental Health Services.

The University of Washington will launch a national search for a new director of ADAI soon; until then, Dr. Caleb Banta-Green, Principal Research Scientist at ADAI, will serve as interim director.

Dennis (aka “Dr. Pun-ovan”)’s retirement will be noted at a party on August 30 with many Seattle colleagues and friends on hand to wish him well.  Thank you, Dennis, for your decades of good work and good cheer at ADAI and for the CTN! Best wishes and happy kayaking!


Gender Differences in Individuals with Opioid Use Disorder Receiving Inpatient Care

August 16, 2018

When looking at profiles of men and women with opioid use disorder (OUD), a number of gender differences become evident. Women report more issues with drug, medical, psychological, family/social, and employment problems, while men report more problems with legal and alcohol-related issues.

Additionally, while there was a 265% increase in prescription opioid overdoses for men between 1999 and 2010, women experienced a 400% increase. Building knowledge of gender differences in demographic and clinical characteristics could help improve outcomes for both men and women in treatment.

This analysis, co-authored by PN Node investigator Mary Hatch-Maillette, PhD (Alcohol & Drug Abuse Institute, UW), examined baseline gender differences in individuals with OUD receiving inpatient services, as part of NIDA Clinical Trials Network protocol CTN-0051, a randomized, controlled trial comparing extended-release naltrexone to buprenorphine. Participants (N=570) provided demographic, substance use, and psychiatric history information.

Results found that the women in the study, compared to the men, were:

  • significantly younger;
  • more likely to identify as bisexual, live with a sexual partner, and be financially dependent on someone else;
  • less likely to be employed;
  • more likely to report psychiatric history (anxiety/panic disorder, bipolar disorder, major depression);
  • more likely to engage in sexual and drug risk behaviors (exchanging sex for drugs, sharing injection equipment).

Women also reported shorter duration, but similar age of onset, of opioid use.

Conclusions: Findings underscore economic, psychiatric, and infection vulnerability among women with OUD, which may complicate treatment initiation, retention, and recovery. Gender-specific interventions focused on these areas of disparity for women with OUD should be considered, including integration of OUD care with treatment for co-occurring psychiatric disorders and trauma, couples-based risk reduction interventions which address relational dynamics, and interventions that address the unique needs of sexual minority women.

Citation: Campbell ANC, et al. Brief Report: Gender differences in demographic and clinical characteristics of patients with opioid use disorder entering a comparative effectiveness medication trial. American Journal on Addictions 2018 (in press).

Find it in the CTN Library!

PrEP Survey Protocol in Development for PNW Node

August 2, 2018


Dr. Mary Hatch-Maillette will be the Co-lead Investigator of the new protocol CTN-0082, Implementation Survey of PrEP and Opioid Use Related Services In STI Clinics and MSM-Centered Community Based Organizations (CBOs), along with Dr. Susan Tross of the Greater New York Node.

While HIV incidence in the broader population in the US decreased by 18%, between 2008 and 2014, among men who have sex with men (MSM), it increased by 6%. Pre-exposure prophylaxis (PrEP) is at the cutting edge of HIV prevention worldwide, yet widespread use and promotion of PrEP has not been widely adopted. Also, despite of current evidence on efficacy of Naloxone and MAT interventions to prevent opioid overdose and treat opioid use disorders (OUD), appropriate models to implement in MSM-Centered CBOs are yet to be identified. Information (e.g. access, readiness, capacity, barriers, resource gaps, etc.) is needed to assist in the effort to increase awareness and use of PrEP and adoption of OUD interventions.

The PrEP Survey study aims to identify health department STI clinics and and/or HIV- centered community-based organizations delivering services to assess: 1) program directors’ and providers’ knowledge/awareness of, interest in, perceived challenges / facilitators to and strategies for, offering PrEP and OUD interventions 2) and MSM’s knowledge / awareness of, interest in, perceived challenges/facilitators to and recommended strategies for, being offered PrEP and OUD interventions.

Clinical sites where the study will be implemented have not yet been announced.