Currently in-press at Drug and Alcohol Dependence, this article by Jessica Dreyfuss, Margaret Griffin, Katherine Frost, and colleagues from the New England Consortium and Greater New York Nodes, as well as Mary Hatch-Maillette, PhD of the Pacific Northwest Node, reports on a secondary analysis of data from protocol CTN-0030 (Prescription Opioid Addiction Treatment Study (POATS)) examining patient characteristics that predict treatment outcome.
Baseline characteristics of 360 patients participating in the study were assessed. In bivariate analyses, pre-treatment characteristics associated with successful opioid use outcome included older age, past-year or lifetime diagnosis of major depressive disorder, initially obtaining opioids with a medical prescription to relieve pain, having only used opioids by swallowing or sublingual administration, never having used heroin, using an opioid other than extended-release oxycodone most frequently, and no prior opioid dependence treatment. In multivariate analysis, age, lifetime major depressive disorder, having only used opioids by swallowing or sublingual administration, and receiving no prior opioid dependence treatment remained as significant predictors of successful outcome.
This is the first study to examine characteristics associated with treatment outcome in patients dependent exclusively on prescription opioids. It is hoped that knowledge about patient characteristics associated with successful (and unsuccessful) outcome from the current study can be used to help develop more effective treatments for this patient population.
Citation: Dreifuss JA, Griffin ML, Frost K, et al. Patient Characteristics Associated with Buprenorphine/Naloxone Treatment Outcome for Prescription Opioid Dependence: Results from a Multisite Study. Drug and Alcohol Dependence 2013 (in press).