Archive for November, 2012

Rationale, Design, and Methodology of the CURB Protocol (CTN-0048)

November 26, 2012

This paper, currently in-press at Contemporary Clinical Trials and co-written by Andrew Saxon of the Pacific Northwest Node, describes the design, methods, and aims of National Drug Abuse Treatment Clinical Trials Network protocol CTN-0048, Cocaine Use Reduction with Buprenorphine (CURB).

CURB was developed to examine the safety and efficacy of sublingual buprenorphine (as Suboxone) in the presence of extended-release injectable naltrexone to see whether that combination reduces cocaine use in adults with both cocaine dependence and opioid use disorders. Investigators also want to determine whether or not the addition of naltrexone prevents development of physiologic dependence on buprenorphine.

Recruitment commenced in September 2011 — Recovery Centers of King County from our node is one of the participating CTPs — and enrollment, active medication, and follow-up phases are ongoing.

Citation: Mooney LJ, Nielsen S, Saxon AJ, et al. Cocaine Use Reduction with Buprenorphine (CURB): Rationale, Design, and Methodology. Contemporary Clinical Trials 2012 (in press).

Find it in the CTN Dissemination Library!


Updates from CTN-0047 Presented at 2012 INEBRIA Conference

November 1, 2012

The 9th Conference of the International Network on Brief Interventions for Alcohol & Other Drugs (INEBRIA), held Barcelona, Spain, September 2012, featured a session about the National Drug Abuse Treatment Clinical Trials Network protocol “Screening Motivational Assessment and Referral to Treatment in Emergency Departments (SMART-ED): Evaluation of Screening, Brief Intervention, Referral to Treatment (SBIRT) and Booster Session for Drug Use Patients Presenting for Treatment” (SMART-ED).

The Pacific Northwest Node is a participant in this protocol, and Node PI Dennis Donovan gave one of the presentations.

Michael Bogenschutz, MD, of the Southwest Node chaired the session, which included presentations about recruitment, enrollment, assessment, training, and challenges experienced by protocol researchers and clinicians:

Recruitment & Retention: SMART-ED, NIDA CTN-0047 — Cameron Crandall, Raul Mandler, Michael Bogenschutz, et al.

Screening, Enrollment, and Assessment in the SMART-ED Study — Robert Lindblad, Ro Shauna Rothwell.

Intervention Training, Supervision and Fidelity Monitoring in NIDA CTN-0047: SMART-ED — Alyssa Forcehimes, Karin Wilson, Theresa Moyers, et al.

Qualitative Reports of Interventionists in the SMART-ED Study: Challenges and Themes — Dennis Donovan, Melissa Phares, Ernie McGarry, et al.

Find them in the CTN Dissemination Library!