Primary Outcomes from POATS (CTN-0030) Published


No randomized trials have examined treatments for prescription opioid dependence, despite its increasing prevalence. This paper, in-press at Archives of General Psychiatry and written by Roger D. Weiss, Jennifer Sharpe Potter, David A. Fiellin, and colleagues, reports on the primary outcomes article from the CTN protocol on this subject, CTN-0030.

This study was a multisite, randomized clinical trial evaluating the efficacy of brief and extended buprenorphine-naloxone treatment, with different counseling intensities, for patients dependent on prescription opioids.  The Pacific Northwest Node’s CTP Providence Behavioral Health Services  served as one of the sites for this study, with William Dickinson, DO one of the paper’s co-authors.

The study found that while prescription opioid-dependent patients are most likely to reduce opioid use during buprenorphine-naloxone treatment, when tapered off the medication, even after 12 weeks of treatment, the likelihood of an unsuccessful outcome is high, regardless of type or amount of counseling.

Read the NIH Press Release about this paper:

Citation: Weiss RD, Potter JS, Fiellin DA, et al. Adjunctive Counseling During Brief and Extended Buprenorphine-Naloxone Treatment for Prescription Opioid Dependence: A 2-Phase Randomized Controlled Trial. Archives of General Psychiatry 2011 (in press).

Find it in the CTN Dissemination Library!



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